Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two new cell-penetrating peptides - RB1 and RB3 - that...

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Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Papale, Alessandro, Morella, Ilaria Maria, Indrigo, Marzia Tina, Bernardi, Rick Eugene, Marrone, Livia, Marchisella, Francesca, Brancale, Andrea, Spanagel, Rainer, Brambilla, Riccardo, Fasano, Stefania
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2016
Ämnen:
Neuroscience
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996650/
https://ncbi.nlm.nih.gov/pubmed/27557444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17111
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