Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting in a Val-Met re...

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Détails bibliographiques
Publié dans:Stem Cells Transl Med
Auteurs principaux: Xu, Maojia, Stattin, Eva-Lena, Shaw, Georgina, Heinegård, Dick, Sullivan, Gareth, Wilmut, Ian, Colman, Alan, Önnerfjord, Patrik, Khabut, Areej, Aspberg, Anders, Dockery, Peter, Hardingham, Timothy, Murphy, Mary, Barry, Frank
Format: Artigo
Langue:Inglês
Publié: AlphaMed Press 2016
Sujets:
Tissue-Specific Progenitor and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996445/
https://ncbi.nlm.nih.gov/pubmed/27388238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0384
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