Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting in a Val-Met re...

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發表在:Stem Cells Transl Med
Main Authors: Xu, Maojia, Stattin, Eva-Lena, Shaw, Georgina, Heinegård, Dick, Sullivan, Gareth, Wilmut, Ian, Colman, Alan, Önnerfjord, Patrik, Khabut, Areej, Aspberg, Anders, Dockery, Peter, Hardingham, Timothy, Murphy, Mary, Barry, Frank
格式: Artigo
語言:Inglês
出版: AlphaMed Press 2016
主題:
Tissue-Specific Progenitor and Stem Cells
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996445/
https://ncbi.nlm.nih.gov/pubmed/27388238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0384
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