Chondrocytes Derived From Mesenchymal Stromal Cells and Induced Pluripotent Cells of Patients With Familial Osteochondritis Dissecans Exhibit an Endoplasmic Reticulum Stress Response and Defective Matrix Assembly

Familial osteochondritis dissecans (FOCD) is an inherited skeletal defect characterized by the development of large cartilage lesions in multiple joints, short stature, and early onset of severe osteoarthritis. It is associated with a heterozygous mutation in the ACAN gene, resulting in a Val-Met re...

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Detalhes bibliográficos
Publicado no:Stem Cells Transl Med
Main Authors: Xu, Maojia, Stattin, Eva-Lena, Shaw, Georgina, Heinegård, Dick, Sullivan, Gareth, Wilmut, Ian, Colman, Alan, Önnerfjord, Patrik, Khabut, Areej, Aspberg, Anders, Dockery, Peter, Hardingham, Timothy, Murphy, Mary, Barry, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2016
Assuntos:
Tissue-Specific Progenitor and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996445/
https://ncbi.nlm.nih.gov/pubmed/27388238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0384
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