p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification

E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment. To further explore the roles of cell adhesion molecules du...

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Publicat a:PLoS Genet
Autors principals: Pieters, Tim, Goossens, Steven, Haenebalcke, Lieven, Andries, Vanessa, Stryjewska, Agata, De Rycke, Riet, Lemeire, Kelly, Hochepied, Tino, Huylebroeck, Danny, Berx, Geert, Stemmler, Marc P., Wirth, Dagmar, Haigh, Jody J., van Hengel, Jolanda, van Roy, Frans
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4996431/
https://ncbi.nlm.nih.gov/pubmed/27556156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006243
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