Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Malignant transformation of the endothelium is rare, and hemangiosarcomas comprise only 1% of all sarcomas. For this reason and due to the lack of appropriate mouse models, the genetic mechanisms of malignant endothelial transformation are poorly understood. Here, we describe a hemangiosarcoma mouse...

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Main Authors: Farhang Ghahremani, Morvarid, Radaelli, Enrico, Haigh, Katharina, Bartunkova, Sonia, Haenebalcke, Lieven, Marine, Jean-Christophe, Goossens, Steven, Haigh, Jody J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050148/
https://ncbi.nlm.nih.gov/pubmed/24626176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28474
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