Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation – continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular v...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Domigan, Courtney K., Warren, Carmen M., Antanesian, Vaspour, Happel, Katharina, Ziyad, Safiyyah, Lee, Sunyoung, Krall, Abigail, Duan, Lewei, Torres-Collado, Antoni X., Castellani, Lawrence W., Elashoff, David, Christofk, Heather R., van der Bliek, Alexander M., Potente, Michael, Iruela-Arispe, M. Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487014/
https://ncbi.nlm.nih.gov/pubmed/25956888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.163774
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