Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation – continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular v...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Domigan, Courtney K., Warren, Carmen M., Antanesian, Vaspour, Happel, Katharina, Ziyad, Safiyyah, Lee, Sunyoung, Krall, Abigail, Duan, Lewei, Torres-Collado, Antoni X., Castellani, Lawrence W., Elashoff, David, Christofk, Heather R., van der Bliek, Alexander M., Potente, Michael, Iruela-Arispe, M. Luisa
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487014/
https://ncbi.nlm.nih.gov/pubmed/25956888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.163774
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