Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation – continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular v...

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Pubblicato in:J Cell Sci
Autori principali: Domigan, Courtney K., Warren, Carmen M., Antanesian, Vaspour, Happel, Katharina, Ziyad, Safiyyah, Lee, Sunyoung, Krall, Abigail, Duan, Lewei, Torres-Collado, Antoni X., Castellani, Lawrence W., Elashoff, David, Christofk, Heather R., van der Bliek, Alexander M., Potente, Michael, Iruela-Arispe, M. Luisa
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487014/
https://ncbi.nlm.nih.gov/pubmed/25956888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.163774
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