Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this s...

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Publicado en:J Exp Med
Autores principales: Chopra, Martin, Biehl, Marlene, Steinfatt, Tim, Brandl, Andreas, Kums, Juliane, Amich, Jorge, Vaeth, Martin, Kuen, Janina, Holtappels, Rafaela, Podlech, Jürgen, Mottok, Anja, Kraus, Sabrina, Jordán-Garrote, Ana-Laura, Bäuerlein, Carina A., Brede, Christian, Ribechini, Eliana, Fick, Andrea, Seher, Axel, Polz, Johannes, Ottmüller, Katja J., Baker, Jeanette, Nishikii, Hidekazu, Ritz, Miriam, Mattenheimer, Katharina, Schwinn, Stefanie, Winter, Thorsten, Schäfer, Viktoria, Krappmann, Sven, Einsele, Hermann, Müller, Thomas D., Reddehase, Matthias J., Lutz, Manfred B., Männel, Daniela N., Berberich-Siebelt, Friederike, Wajant, Harald, Beilhack, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995078/
https://ncbi.nlm.nih.gov/pubmed/27526711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151563
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