Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity

Graft-versus-host disease (GvHD) is a life-threatening immunological complication after allogenic hematopoietic stem cell transplantation (allo-HCT). The intrinsic graft-versus-leukemia (GvL) effect, however, is the desirable curative benefit. Patients with acute GvHD are treated with cyclosporine A...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Vaeth, Martin, Bäuerlein, Carina A., Pusch, Tobias, Findeis, Janina, Chopra, Martin, Mottok, Anja, Rosenwald, Andreas, Beilhack, Andreas, Berberich-Siebelt, Friederike
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313840/
https://ncbi.nlm.nih.gov/pubmed/25583478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409290112
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