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Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity
Graft-versus-host disease (GvHD) is a life-threatening immunological complication after allogenic hematopoietic stem cell transplantation (allo-HCT). The intrinsic graft-versus-leukemia (GvL) effect, however, is the desirable curative benefit. Patients with acute GvHD are treated with cyclosporine A...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4313840/ https://ncbi.nlm.nih.gov/pubmed/25583478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409290112 |
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