An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, Eph, and erbB families, thereby activating signaling pathways critical for tumor initiation and maintenance. ADAM10 is thus a promising therapeutic target. Although widely e...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Atapattu, Lakmali, Saha, Nayanendu, Chheang, Chanly, Eissman, Moritz F., Xu, Kai, Vail, Mary E., Hii, Linda, Llerena, Carmen, Liu, Zhanqi, Horvay, Katja, Abud, Helen E., Kusebauch, Ulrike, Moritz, Robert L., Ding, Bi-Sen, Cao, Zhongwei, Rafii, Shahin, Ernst, Matthias, Scott, Andrew M., Nikolov, Dimitar B., Lackmann, Martin, Janes, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995075/
https://ncbi.nlm.nih.gov/pubmed/27503072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151095
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