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Molecular recordings by directed CRISPR spacer acquisition

The ability to write a stable record of identified molecular events into a specific genomic locus would enable the examination of long cellular histories and have many applications, ranging from developmental biology to synthetic devices. We show that the type I-E CRISPR-Cas system of E. coli can me...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Shipman, Seth L, Nivala, Jeff, Macklis, Jeffrey D, Church, George M
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994893/
https://ncbi.nlm.nih.gov/pubmed/27284167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf1175
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