Methylated Cytosines Mutate to Transcription Factor Binding Sites that Drive Tetrapod Evolution

In mammals, the cytosine in CG dinucleotides is typically methylated producing 5-methylcytosine (5mC), a chemically less stable form of cytosine that can spontaneously deaminate to thymidine resulting in a T•G mismatched base pair. Unlike other eukaryotes that efficiently repair this mismatched base...

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Pubblicato in:Genome Biol Evol
Autori principali: He, Ximiao, Tillo, Desiree, Vierstra, Jeff, Syed, Khund-Sayeed, Deng, Callie, Ray, G. Jordan, Stamatoyannopoulos, John, FitzGerald, Peter C., Vinson, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994754/
https://ncbi.nlm.nih.gov/pubmed/26507798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evv205
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