Methylated Cytosines Mutate to Transcription Factor Binding Sites that Drive Tetrapod Evolution

In mammals, the cytosine in CG dinucleotides is typically methylated producing 5-methylcytosine (5mC), a chemically less stable form of cytosine that can spontaneously deaminate to thymidine resulting in a T•G mismatched base pair. Unlike other eukaryotes that efficiently repair this mismatched base...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Genome Biol Evol
Hauptverfasser: He, Ximiao, Tillo, Desiree, Vierstra, Jeff, Syed, Khund-Sayeed, Deng, Callie, Ray, G. Jordan, Stamatoyannopoulos, John, FitzGerald, Peter C., Vinson, Charles
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994754/
https://ncbi.nlm.nih.gov/pubmed/26507798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evv205
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge