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5-Methylcytosine (5mC) and 5-Hydroxymethylcytosine (5hmC) Enhance the DNA Binding of CREB1 to the C/EBP Half-Site Tetranucleotide GCAA

In human and mouse stem cells and brain, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) can occur outside of CG dinucleotides. Using protein binding microarrays (PBMs) containing 60-mer DNA probes, we evaluated the effect of 5mC and 5hmC on one DNA strand on the double-stranded DNA bindin...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Syed, Khund Sayeed, He, Ximiao, Tillo, Desiree, Wang, Jun, Durell, Stewart R., Vinson, Charles
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781525/
https://ncbi.nlm.nih.gov/pubmed/27951657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00796
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