The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory

UHRF2 has been implicated as a novel regulator for both DNA methylation (5mC) and hydroxymethylation (5hmC), but its physiological function and role in DNA methylation/hydroxymethylation are unknown. Here we show that in mice, UHRF2 is more abundantly expressed in the brain and a few other tissues....

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Chen, Ruoyu, Zhang, Qiao, Duan, Xiaoya, York, Philippe, Chen, Guo-Dong, Yin, Pengcheng, Zhu, Haijun, Xu, Meichen, Chen, Peilin, Wu, Qihan, Li, Dali, Samarut, Jacques, Xu, Guoliang, Zhang, Pumin, Cao, Xiaohua, Li, Jiwen, Wong, Jiemin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Gene Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377770/
https://ncbi.nlm.nih.gov/pubmed/28115522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754580
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