C/EBPβ (CEBPB) protein binding to the C/EBP|CRE DNA 8-mer TTGC|GTCA is inhibited by 5hmC and enhanced by 5mC, 5fC, and 5caC in the CG dinucleotide.

During mammalian development, some methylated cytosines (5mC) in CG dinucleotides are iteratively oxidized by TET dioxygenases to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). The effect of these cytosine oxidative products on the sequence-specific DNA bindin...

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Vydáno v:Biochim Biophys Acta
Hlavní autoři: Khund Sayeed, Syed, Zhao, Jianfei, Sathyanarayana, Bangalore K., Golla, Jaya Prakash, Vinson, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857639/
https://ncbi.nlm.nih.gov/pubmed/25779641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2015.03.002
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