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Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

The diiron cluster-containing oxygenase CmlI catalyzes the conversion of the aromatic amine precursor of chloramphenicol to the nitroaromatic moiety of the active antibiotic. The X-ray crystal structures of the fully active, N-terminally truncated CmlIΔ33 in the chemically reduced Fe(2+)/Fe(2+) stat...

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Publicat a:J Biol Inorg Chem
Autors principals: Knoot, Cory J., Kovaleva, Elena G., Lipscomb, John D.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994471/
https://ncbi.nlm.nih.gov/pubmed/27229511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-016-1363-x
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