Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Immune checkpoint inhibitors, which unleash a patient’s own T cells to kill tumors, are revolutionizing cancer treatment. To unravel the genomic determinants of response to this therapy, we used whole-exome sequencing of non–small cell lung cancers treated with pembrolizumab, an antibody targeting p...

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書誌詳細
出版年:Science
主要な著者: Rizvi, Naiyer A., Hellmann, Matthew D., Snyder, Alexandra, Kvistborg, Pia, Makarov, Vladimir, Havel, Jonathan J., Lee, William, Yuan, Jianda, Wong, Phillip, Ho, Teresa S., Miller, Martin L., Rekhtman, Natasha, Moreira, Andre L., Ibrahim, Fawzia, Bruggeman, Cameron, Gasmi, Billel, Zappasodi, Roberta, Maeda, Yuka, Sander, Chris, Garon, Edward B., Merghoub, Taha, Wolchok, Jedd D., Schumacher, Ton N., Chan, Timothy A.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993154/
https://ncbi.nlm.nih.gov/pubmed/25765070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa1348
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