Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) mutation

Fibrodysplasia Ossificans Progressiva (FOP) is a rare and as yet untreatable, genetic disorder of progressive extraskeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans and causes skeletal deformities, movement impairment and premature death. Most FOP patients...

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Publicado en:J Bone Miner Res
Autores principales: Chakkalakal, Salin A., Uchibe, Kenta, Convente, Michael R., Zhang, Deyu, Economides, Aris N., Kaplan, Frederick S., Pacifici, Maurizio, Iwamoto, Masahiro, Shore, Eileen M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992469/
https://ncbi.nlm.nih.gov/pubmed/26896819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2820
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