Palovarotene inhibits heterotopic ossification and maintains limb mobility and growth in mice with the human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) mutation

Fibrodysplasia Ossificans Progressiva (FOP) is a rare and as yet untreatable, genetic disorder of progressive extraskeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans and causes skeletal deformities, movement impairment and premature death. Most FOP patients...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Bone Miner Res
Prif Awduron: Chakkalakal, Salin A., Uchibe, Kenta, Convente, Michael R., Zhang, Deyu, Economides, Aris N., Kaplan, Frederick S., Pacifici, Maurizio, Iwamoto, Masahiro, Shore, Eileen M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992469/
https://ncbi.nlm.nih.gov/pubmed/26896819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2820
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