Essential roles for Polymerase θ mediated end-joining in repair of chromosome breaks

DNA Polymerase theta (Pol θ) mediated end-joining (TMEJ) has been implicated in repair of chromosome breaks, but its cellular mechanism and role relative to canonical repair pathways is poorly understood. We show it accounts for most repair associated with microhomologies, and is made efficient by c...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wyatt, David W., Feng, Wanjuan, Conlin, Michael P., Yousefzadeh, Matthew J., Roberts, Steven A., Mieczkowski, Piotr, Wood, Richard D., Gupta, Gaorav P., Ramsden, Dale A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992412/
https://ncbi.nlm.nih.gov/pubmed/27453047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.06.020
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