PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind D...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992063/
https://ncbi.nlm.nih.gov/pubmed/27530147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12404
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