PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2)

PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal that PARP3 employs a conserved DNA-binding interface to detect and stably bind D...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Grundy, Gabrielle J., Polo, Luis M., Zeng, Zhihong, Rulten, Stuart L., Hoch, Nicolas C., Paomephan, Pathompong, Xu, Yingqi, Sweet, Steve M., Thorne, Alan W., Oliver, Antony W., Matthews, Steve J., Pearl, Laurence H., Caldecott, Keith W.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992063/
https://ncbi.nlm.nih.gov/pubmed/27530147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12404
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