Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells

Sphingosine kinase 2 (Sphk2) has an oncogenic role in cancer. A recently developed first-in-class Sphk2 specific inhibitor ABC294640 displays antitumor activity in many cancer models. However, the role of Sphk2 and the antitumor activity of its inhibitor ABC294640 are not known in cholangiocarcinoma...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ding, Xiwei, Chaiteerakij, Roongruedee, Moser, Catherine D., Shaleh, Hassan, Boakye, Jeffrey, Chen, Gang, Ndzengue, Albert, Li, Ying, Zhou, Yanling, Huang, Shengbing, Sinicrope, Frank A., Zou, Xiaoping, Thomas, Melanie B., Smith, Charles D., Roberts, Lewis R.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991440/
https://ncbi.nlm.nih.gov/pubmed/26956050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7914
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