Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells

Sphingosine kinase 2 (Sphk2) has an oncogenic role in cancer. A recently developed first-in-class Sphk2 specific inhibitor ABC294640 displays antitumor activity in many cancer models. However, the role of Sphk2 and the antitumor activity of its inhibitor ABC294640 are not known in cholangiocarcinoma...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Ding, Xiwei, Chaiteerakij, Roongruedee, Moser, Catherine D., Shaleh, Hassan, Boakye, Jeffrey, Chen, Gang, Ndzengue, Albert, Li, Ying, Zhou, Yanling, Huang, Shengbing, Sinicrope, Frank A., Zou, Xiaoping, Thomas, Melanie B., Smith, Charles D., Roberts, Lewis R.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991440/
https://ncbi.nlm.nih.gov/pubmed/26956050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7914
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