Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma

BACKGROUND: Fibroblast growth factor receptor 2 (FGFR2) genetic alterations lead to tumor cell proliferation in various types of cancer. We hypothesized that FGFR2 amplification is associated with FGFR2 expression, resulting in tumor growth and poorer outcome in esophagogastric junction (EGJ) adenoc...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tokunaga, Ryuma, Imamura, Yu, Nakamura, Kenichi, Ishimoto, Takatsugu, Nakagawa, Shigeki, Miyake, Keisuke, Nakaji, Yu, Tsuda, Yasuo, Iwatsuki, Masaaki, Baba, Yoshifumi, Sakamoto, Yasuo, Miyamoto, Yuji, Saeki, Hiroshi, Yoshida, Naoya, Oki, Eiji, Watanabe, Masayuki, Oda, Yoshinao, Bass, Adam J., Maehara, Yoshihiko, Baba, Hideo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991416/
https://ncbi.nlm.nih.gov/pubmed/26933914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7782
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