LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis

BACKGROUND: Genome-wide DNA hypomethylation plays an important role in genomic instability and carcinogenesis. DNA methylation in the long interspersed nucleotide element-1, L1 (LINE-1) repetitive element is a good indicator of the global DNA methylation level. In some types of human neoplasms, LINE...

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Main Authors: Shigaki, Hironobu, Baba, Yoshifumi, Watanabe, Masayuki, Murata, Asuka, Iwagami, Shiro, Miyake, Keisuke, Ishimoto, Takatsugu, Iwatsuki, Masaaki, Baba, Hideo
Format: Artigo
Language:Inglês
Published: Springer Japan 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824342/
https://ncbi.nlm.nih.gov/pubmed/23179365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-012-0209-7
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