Fibroblast growth factor receptor 2 expression, but not its genetic amplification, is associated with tumor growth and worse survival in esophagogastric junction adenocarcinoma

BACKGROUND: Fibroblast growth factor receptor 2 (FGFR2) genetic alterations lead to tumor cell proliferation in various types of cancer. We hypothesized that FGFR2 amplification is associated with FGFR2 expression, resulting in tumor growth and poorer outcome in esophagogastric junction (EGJ) adenoc...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Tokunaga, Ryuma, Imamura, Yu, Nakamura, Kenichi, Ishimoto, Takatsugu, Nakagawa, Shigeki, Miyake, Keisuke, Nakaji, Yu, Tsuda, Yasuo, Iwatsuki, Masaaki, Baba, Yoshifumi, Sakamoto, Yasuo, Miyamoto, Yuji, Saeki, Hiroshi, Yoshida, Naoya, Oki, Eiji, Watanabe, Masayuki, Oda, Yoshinao, Bass, Adam J., Maehara, Yoshihiko, Baba, Hideo
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991416/
https://ncbi.nlm.nih.gov/pubmed/26933914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7782
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