Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells

The metastatic cascade describes the escape of primary tumour cells to distant secondary sites. Cells at the leading tumour edge are thought to undergo epithelial-mesenchymal transition (EMT), to enhance their motility and invasion for spreading. Whether EMT cells directly promote tumour angiogenesi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Gopal, Shashi K., Greening, David W., Hanssen, Eric G., Zhu, Hong-Jian, Simpson, Richard J., Mathias, Rommel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991413/
https://ncbi.nlm.nih.gov/pubmed/26919098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7573
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