Immediate Dysfunction of Vaccine-Elicited CD8(+) T Cells Primed in the Absence of CD4(+) T Cells

CD4(+) T cell help is critical for optimal CD8(+) T cell memory differentiation and maintenance in many experimental systems. In addition, many reports have identified reduced primary CD8(+) T cell responses in the absence of CD4(+) T cell help, which often coincides with reduced Ag or pathogen clea...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Provine, Nicholas M., Larocca, Rafael A., Aid, Malika, Penaloza-MacMaster, Pablo, Badamchi-Zadeh, Alexander, Borducchi, Erica N., Yates, Kathleen B., Abbink, Peter, Kirilova, Marinela, Ng’ang’a, David, Bramson, Jonathan, Haining, W. Nicholas, Barouch, Dan H.
Format: Artigo
Langue:Inglês
Publié: AAI 2016
Sujets:
Infectious Disease and Host Response
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991249/
https://ncbi.nlm.nih.gov/pubmed/27448585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600591
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