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Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4(+) T cell responses that impair CD8(+) T cell function
Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8(+) T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8(+) T cells has not previously been elucidated. Here we demonstrat...
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| Pubblicato in: | Sci Immunol |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5322800/ https://ncbi.nlm.nih.gov/pubmed/28239679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf7643 |
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