Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4(+) T cell responses that impair CD8(+) T cell function

Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8(+) T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8(+) T cells has not previously been elucidated. Here we demonstrat...

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Gepubliceerd in:Sci Immunol
Hoofdauteurs: Larocca, Rafael A., Provine, Nicholas M., Aid, Malika, Iampietro, M. Justin, Borducchi, Erica N., Badamchi-Zadeh, Alexander, Abbink, Peter, Ng’ang’a, David, Bricault, Christine A., Blass, Eryn, Penaloza-MacMaster, Pablo, Stephenson, Kathryn E., Barouch, Dan H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322800/
https://ncbi.nlm.nih.gov/pubmed/28239679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaf7643
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