Transient CD4(+) T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses

We have recently demonstrated that CD4(+) T cell help is required at the time of adenovirus (Ad) vector immunization for the development of functional CD8(+) T cell responses, but the temporal requirement for CD4(+) T cell help for the induction of antibody responses remains unclear. Here we demonst...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Provine, Nicholas M., Badamchi-Zadeh, Alexander, Bricault, Christine A., Penaloza-MacMaster, Pablo, Larocca, Rafael A., Borducchi, Erica N., Seaman, Michael S., Barouch, Dan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836333/
https://ncbi.nlm.nih.gov/pubmed/26865713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00039-16
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