Augmented Replicative Capacity of the Boosting Antigen Improves the Protective Efficacy of Heterologous Prime-Boost Vaccine Regimens

Prime-boost immunization regimens have proven efficacious at generating robust immune responses. However, whether the level of replication of the boosting antigen impacts the magnitude and protective efficacy of vaccine-elicited immune responses remains unclear. To evaluate this, we primed mice with...

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Detalhes bibliográficos
Main Authors: Penaloza-MacMaster, Pablo, Teigler, Jeffrey E., Obeng, Rebecca C., Kang, Zi H., Provine, Nicholas M., Parenteau, Lily, Blackmore, Stephen, Ra, Joshua, Borducchi, Erica N., Barouch, Dan H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4093883/
https://ncbi.nlm.nih.gov/pubmed/24648461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00406-14
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