A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain

Factor XI (FXI) is the zymogen of FXIa, which cleaves FIX in the intrinsic pathway of coagulation. FXI is known to exist as a dimer and interacts with multiple proteins via its 4 apple domains in the “saucer section” of the enzyme; however, to date, no complex crystal structure has been described. T...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood
Prif Awduron: Wong, Szu S., Østergaard, Søren, Hall, Gareth, Li, Chan, Williams, Philip M., Stennicke, Henning, Emsley, Jonas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2016
Pynciau:
Thrombosis and Hemostasis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991086/
https://ncbi.nlm.nih.gov/pubmed/27006387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-10-676122
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