A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium

PURPOSE: Noncoding microRNAs (miRNAs) have been implicated in the pathogenesis of glaucoma. We aimed to identify common variants in miRNA coding genes (MIR) associated with primary open-angle glaucoma (POAG). METHODS: Using the NEIGHBORHOOD data set (3853 cases/33,480 controls with European ancestry...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Liu, Yutao, Bailey, Jessica Cooke, Helwa, Inas, Dismuke, W. Michael, Cai, Jingwen, Drewry, Michelle, Brilliant, Murray H., Budenz, Donald L., Christen, William G., Chasman, Daniel I., Fingert, John H., Gaasterland, Douglas, Gaasterland, Terry, Gordon, Mae O., Igo, Robert P., Kang, Jae H., Kass, Michael A., Kraft, Peter, Lee, Richard K., Lichter, Paul, Moroi, Sayoko E., Realini, Anthony, Richards, Julia E., Ritch, Robert, Schuman, Joel S., Scott, William K., Singh, Kuldev, Sit, Arthur J., Song, Yeunjoo E., Vollrath, Douglas, Weinreb, Robert, Medeiros, Felipe, Wollstein, Gadi, Zack, Donald J., Zhang, Kang, Pericak-Vance, Margaret A., Gonzalez, Pedro, Stamer, W. Daniel, Kuchtey, John, Kuchtey, Rachel W., Allingham, R. Rand, Hauser, Michael A., Pasquale, Louis R., Haines, Jonathan L., Wiggs, Janey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2016
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991020/
https://ncbi.nlm.nih.gov/pubmed/27537254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19688
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