Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma

PURPOSE: Brn3b is a class IV POU domain transcription factor that plays an important role in the development of retinal ganglion cells (RGCs), RGC survival, and particularly axon growth and pathfinding. Our previous study demonstrated that recombinant adenoassociated virus serotype 2 (rAAV-2)–mediat...

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Udgivet i:Mol Vis
Main Authors: Phatak, Nitasha R., Stankowska, Dorota L., Krishnamoorthy, Raghu R.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Vision 2016
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990101/
https://ncbi.nlm.nih.gov/pubmed/27587945
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