CAG repeat size in Huntingtin alleles is associated with cancer prognosis

The abnormal expansion of a ≥36 CAG unit tract in the Huntingtin gene (HTT) leads to Huntington's disease (HD), but has also been associated with cancer: the incidence of cancer is lower in HD patients than in age-matched controls, but HD-causing variants of HTT accelerate the progression of br...

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Publicado en:Eur J Hum Genet
Autores principales: Thion, Morgane Sonia, Tézenas du Montcel, Sophie, Golmard, Jean-Louis, Vacher, Sophie, Barjhoux, Laure, Sornin, Valérie, Cazeneuve, Cécile, Bièche, Ivan, Sinilnikova, Olga, Stoppa-Lyonnet, Dominique, Durr, Alexandra, Humbert, Sandrine
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989202/
https://ncbi.nlm.nih.gov/pubmed/26980106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2016.13
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