Загрузка...

Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat

Huntington's disease (HD) is a currently incurable neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat within the huntingtin (HTT) gene. Therapeutic approaches include selectively inhibiting the expression of the mutated HTT allele while conserving function of the no...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Gagnon, Keith T., Pendergraff, Hannah M., Deleavey, Glen F., Swayze, Eric E., Potier, Pierre, Randolph, John, Roesch, Eric B., Chattopadhyaya, Jyoti, Damha, Masad J., Bennett, C. Frank, Montaillier, Christophe, Lemaitre, Marc, Corey, David R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991413/
https://ncbi.nlm.nih.gov/pubmed/21028906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101208k
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!