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Huntingtin Regulates Mammary Stem Cell Division and Differentiation

Little is known about the mechanisms of mitotic spindle orientation during mammary gland morphogenesis. Here, we report the presence of huntingtin, the protein mutated in Huntington’s disease, in mouse mammary basal and luminal cells throughout mammogenesis. Keratin 5-driven depletion of huntingtin...

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Detalhes bibliográficos
Main Authors: Elias, Salah, Thion, Morgane S., Yu, Hua, Sousa, Cristovao Marques, Lasgi, Charlène, Morin, Xavier, Humbert, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986500/
https://ncbi.nlm.nih.gov/pubmed/24749073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.02.011
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