Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

A polyglutamine expansion in huntingtin (HTT) causes the specific death of adult neurons in Huntington's disease (HD). Most studies have thus focused on mutant HTT (mHTT) toxicity in adulthood, and its developmental effects have been largely overlooked. We found that mHTT caused mitotic spindle...

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Vydáno v:J Neurosci
Hlavní autoři: Molina-Calavita, Maria, Barnat, Monia, Elias, Salah, Aparicio, Esther, Piel, Matthieu, Humbert, Sandrine
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
Témata:
Brief Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608303/
https://ncbi.nlm.nih.gov/pubmed/25057205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0715-14.2014
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