Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex

A polyglutamine expansion in huntingtin (HTT) causes the specific death of adult neurons in Huntington's disease (HD). Most studies have thus focused on mutant HTT (mHTT) toxicity in adulthood, and its developmental effects have been largely overlooked. We found that mHTT caused mitotic spindle...

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Опубликовано в: :J Neurosci
Главные авторы: Molina-Calavita, Maria, Barnat, Monia, Elias, Salah, Aparicio, Esther, Piel, Matthieu, Humbert, Sandrine
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2014
Предметы:
Brief Communications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608303/
https://ncbi.nlm.nih.gov/pubmed/25057205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0715-14.2014
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