Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance

Ohnologs –paralogous gene pairs generated by whole genome duplication– are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating...

Full description

Saved in:
Bibliographic Details
Published in:Mol Biol Evol
Main Authors: Xie, Ting, Yang, Qing-Yong, Wang, Xiao-Tao, McLysaght, Aoife, Zhang, Hong-Yu
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Discoveries
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989111/
https://ncbi.nlm.nih.gov/pubmed/27297469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw108
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items