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Dosage-sensitive genes in evolution and disease

For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typically they are associated with disease, including heart disease, cancers and neuropsychiatri...

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Pubblicato in:BMC Biol
Autori principali: Rice, Alan M., McLysaght, Aoife
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5580218/
https://ncbi.nlm.nih.gov/pubmed/28863777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-017-0418-y
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