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Ohnologs in the human genome are dosage balanced and frequently associated with disease

About 30% of protein-coding genes in the human genome are related through two whole genome duplication (WGD) events. Although WGD is often credited with great evolutionary importance, the processes governing the retention of these genes and their biological significance remain unclear. One increasin...

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Detalhes bibliográficos
Main Authors: Makino, Takashi, McLysaght, Aoife
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889102/
https://ncbi.nlm.nih.gov/pubmed/20439718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914697107
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