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Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance
Ohnologs –paralogous gene pairs generated by whole genome duplication– are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating...
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| Udgivet i: | Mol Biol Evol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4989111/ https://ncbi.nlm.nih.gov/pubmed/27297469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw108 |
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