Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion

BACKGROUND AND PURPOSE: Cardiovascular disease is the leading cause of death worldwide, mainly due to an increasing prevalence of atherosclerosis characterized by inflammatory plaques. Plaques with high levels of macrophage infiltration are considered “vulnerable” while those that do not have signif...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Abd-Elrahman, Ihab, Kosuge, Hisanori, Wises Sadan, Tommy, Ben-Nun, Yael, Meir, Karen, Rubinstein, Chen, Bogyo, Matthew, McConnell, Michael V., Blum, Galia
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988760/
https://ncbi.nlm.nih.gov/pubmed/27532109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160522
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