FGF13 modulates the gating properties of the cardiac sodium channel Na(v)1.5 in an isoform-specific manner

FGF13 (FHF2), the major fibroblast growth factor homologous factor (FHF) in rodent heart, directly binds to the C-terminus of the main cardiac sodium channel, Na(V)1.5. Knockdown of FGF13 in cardiomyocytes induces slowed ventricular conduction by altering Na(V)1.5 function. FGF13 has five splice var...

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Publicado en:Channels (Austin)
Autores principales: Yang, Jing, Wang, Zhihua, Sinden, Daniel S., Wang, Xiangchong, Shan, Bin, Yu, Xiao, Zhang, Hailin, Pitt, Geoffrey S., Wang, Chuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988462/
https://ncbi.nlm.nih.gov/pubmed/27246624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2016.1190055
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