AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV as...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Di Micco, Antonia, Frera, Gianluca, Lugrin, Jérôme, Jamilloux, Yvan, Hsu, Erh-Ting, Tardivel, Aubry, De Gassart, Aude, Zaffalon, Léa, Bujisic, Bojan, Siegert, Stefanie, Quadroni, Manfredo, Broz, Petr, Henry, Thomas, Hrycyna, Christine A., Martinon, Fabio
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987819/
https://ncbi.nlm.nih.gov/pubmed/27462105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602419113
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