AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

Inflammasomes are critical sensors that convey cellular stress and pathogen presence to the immune system by activating inflammatory caspases and cytokines such as IL-1β. The nature of endogenous stress signals that activate inflammasomes remains unclear. Here we show that an inhibitor of the HIV as...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Di Micco, Antonia, Frera, Gianluca, Lugrin, Jérôme, Jamilloux, Yvan, Hsu, Erh-Ting, Tardivel, Aubry, De Gassart, Aude, Zaffalon, Léa, Bujisic, Bojan, Siegert, Stefanie, Quadroni, Manfredo, Broz, Petr, Henry, Thomas, Hrycyna, Christine A., Martinon, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987819/
https://ncbi.nlm.nih.gov/pubmed/27462105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602419113
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